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Which is the statin with the least side effects? In the analysis of 135 previous studies, which included nearly 250,000 people combined, researchers found that the drugs simvastatin (Zocor) and pravastatin (Pravachol) had the fewest side effects in this class of medications. They also found that lower doses produced fewer side effects in general.
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What can be substituted for statins? Beyond statins: Assessing the alternatives Statin substitutes? But about 10% of people who try statins experience bothersome side effects (most commonly, muscle aches) that prevent them from taking these useful drugs. Ezetimibe. Ezetimibe (Zetia) lowers LDL by about 20%. Bile acid binders. Fibrates. Niacin.
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