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What can be substituted for statins? Beyond statins: Assessing the alternatives Statin substitutes? But about 10% of people who try statins experience bothersome side effects (most commonly, muscle aches) that prevent them from taking these useful drugs. Ezetimibe. Ezetimibe (Zetia) lowers LDL by about 20%. Bile acid binders. Fibrates. Niacin.
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